IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. The livers of PTSD rats had reduced glycogen content. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. Posttraumatic stress disorder (PTSD) causes mental and somatic diseases.
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